The Origins of a Breast Cancer Gene

Pregnancy first trimesterThe BRCA1 modification . . . was originally described as a originator modification in the Ashkenazi person population. However, this modification is also inform at appreciable frequency in individualist dweller countries, which raises intriguing questions most the origins of the mutation. We genotyped 245 carrier families from 14 assorted accumulation groups (Russian, Latvian, Ukrainian, Czech, Slovak, Polish, Danish, Dutch, French, German, Italian, Greek, Brazilian and Ashkenazi Jewish) . . . and confirmed that every modification carriers share a common haplotype from a single originator individual. . . . [T]he modification arose some 1800 eld ago [200 CE] in either peninsula or what is today Federal country and afterward distribute to the different populations we genotyped during the mass centuries, including the Ashkenazi person population. Age estimates and the molecular evolution profile of the most common linked haplotype in the carrier populations studied boost declare that [the mutation] likely entered the Ashkenazi person factor bet in Polska roughly 400â€"500 eld ago [1500 CE - 1600 CE].From here.Copyright Andrew Oh-Willeke (2009)Pregnancy info
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